Mouse Mutants Lacking the Type 2 IGF Receptor (IGF2R) Are Rescued from Perinatal Lethality in Igf2 and Igf1r Null Backgrounds
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چکیده
منابع مشابه
Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues.
Mouse embryos nullizygous for a targeted disruption of the Huntington's disease gene homologue (Hdh), which encodes a protein (huntingtin) of unknown biochemical function, become developmentally retarded and disorganized, and die early in development. Using chimeric analysis, we demonstrate that extensively chimeric embryos derived by injection of Hdh null ES cells into wild-type host blastocys...
متن کاملارتباط پلی مورفیسم3'UTR(C>A) از ژن گیرنده (IGF2R)IGF2 با شاخص‌های مقاومت به انسولین در بیماران مبتلا به دیابت نوع2 و افراد غیردیابتی
Background and objective: Association of 6q loci, where IGF2R gene is located, with insulin resistance has been well established. In this study, relationship between 3'UTR and type 2 diabetes and insulin resistance indices in non diabetic subjects was investigated. Materials and Methods: 350 participants (175 diabetic type 2 patient and 175 non-diabetic individuals) were entered in this study. ...
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Erythropoietin (Epo) and its receptor (EpoR) are indispensable to erythropoiesis. Although roles besides angiogenesis, such as neuroprotection and heart development, have been reported for the Epo-EpoR system, the precise contribution of Epo-EpoR to these nonhematopoietic tissues requires clarification. Exploiting a GATA-1 minigene cassette with hematopoietic regulatory domains, we established ...
متن کاملEmbryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2.
The ryanodine receptor type 2 (RyR-2) functions as a Ca2+-induced Ca2+ release (CICR) channel on intracellular Ca2+ stores and is distributed in most excitable cells with the exception of skeletal muscle cells. RyR-2 is abundantly expressed in cardiac muscle cells and is thought to mediate Ca2+ release triggered by Ca2+ influx through the voltage-gated Ca2+ channel to constitute the cardiac typ...
متن کاملMaternal Transmission of a Humanised Igf2r Allele Results in an Igf2 Dependent Hypomorphic and Non-Viable Growth Phenotype
The cation independent mannose 6-phosphate/insulin-like growth factor 2 receptor (IGF2R) functions in the transportation and regulation of insulin-like growth factor 2 (IGF2) and mannose 6-phosphate modified proteins. The relative and specific titration of IGF2 by high affinity binding of IGF2R represents a mechanism that supports the parental conflict theory of genomic imprinting. Imprinting o...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 1996
ISSN: 0012-1606
DOI: 10.1006/dbio.1996.0182